Biomedical Engineering

Computational anatomy and diffeomorphometry: Embedding the brain into the soft condensed matter continuum

November 29, 2018

10:30 a.m. - 11:30 a.m. ET

136A Baker Hall

Speaker

Michael I. Miller, Ph.D. 
Director, Center for Imaging Science
Co-Director, Kavli Neuroscience Discovery Institute
Johns Hopkins University

Abstract

I will discuss the central model of computational anatomy, the study of anatomical shape and form via the group action of diffeomorphisms. We will attempt to show two applications (time permitting), the first using the diffeomorphisms to define a Geodesic Positioning System at the heart of MRICloud, a big-data application for indexing pediatric and geriatric brains, and the second using the diffeomorphisms to study Alzheimer’s disease in a population of 360 pre-clinical subjects examined since 1995. We will show (time permitting) how geodesics in the group reveal the generalized Euler Equation (1755), generalized for compressibility allowing for growth and atrophy.

 

BME seminar series

Upcoming Events